Significant association of glutathione s-transferase

BACKGROUND:

Recent studies on the association  between Glutathione S-transferase T1 (GSTT1) polymorphism and risk of  prostate cancer showed inconclusive results. To clarify this possible  association, we conducted a meta-analysis of published studies.

METHODS:

DATA  WERE COLLECTED FROM THE FOLLOWING ELECTRONIC DATABASES: Pubmed, Embase,  and Chinese Biomedical Database (CBM). The odds ratio (OR) and its 95%  confidence interval (95%CI) was used to assess the strength of the  association. We summarized the data on the association between GSTT1  null genotype and risk of prostate cancer in the overall population, and  performed subgroup analyses by ethnicity, adjusted ORs, and types of  controls.天津医科大学肿瘤医院泌尿肿瘤科杜君

RESULTS:

Ultimately, a total of 43 studies with  a total of 26,393 subjects (9,934 cases and 16,459 controls) were  eligible for meta-analysis. Overall, there was a significant association  between GSTT1 null genotype and increased risk of prostate cancer  (OR = 1.14, 95%CI 1.01-1.29, P = 0.034). Meta-analysis of adjusted ORs  also showed a significant association between GSTT1 null genotype and  increased risk of prostate cancer (OR = 1.34, 95%CI 1.09-1.64,  P = 0.006). Similar results were found in the subgroup analyses by  ethnicity and types of controls.

CONCLUSION:

This  meta-analysis demonstrates that GSTT1 null genotype is associated with  prostate cancer susceptibility, and GSTT1 null genotype contributes to  increased risk of prostate cancer.